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Download PDF Sex is just as complicated as humans are. From a biological standpoint, the appearance of the external genitalia is only one parameter among many, including chromosomal constitution, the sequence of sex-determining genes, gonadal structure, the profile of gonadal hormones, and the internal reproductive structures. One of the pillars of the modern scientific method is to test models and try to prove them wrong. Human sexual anatomy was categorized into five types in the 19th century. An individual could be a female or a male with typical feminine or masculine external genitalia, respectivelya female or male pseudohermaphrodite, or a true hermaphrodite. True hermaphrodites have both testicular and ovarian tissue. As noted by Dreger, 2 this model, centered on the gonadal anatomy, was adopted by clinicians, and all patients born with ambiguous genitalia were traditionally classified into one of these categories. For example, individuals born with Congenital Adrenal Hyperplasia have been categorized as female pseudohermaphrodites. However, scientific advances of the past half century have shown that this model, taking into consideration exclusively the type of gonads, is inaccurate.

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